Dr. Ruffolo is the retired President of Research & Development of Wyeth Pharmaceuticals and Senior Vice President of the Wyeth Corporation (now Pfizer). At Wyeth, he managed an R&D organization of 9,000 scientists and an annual budget of $3 billion. He received numerous awards during his long career. He was awarded the prestigious John Jacob Abel Award by the American Society for Pharmacology and Experimental Therapeutics (ASPET), and he was recognized in by the Pharmaceutical Research and Manufacturers of America (PhRMA) with their highest award, the Discoverer’s Award, for his pioneering research on the discovery and development of carvedilol (Coreg®). Carvedilol has become the standard of care for the treatment of congestive heart failure. He was named Chief Scientific Officer of the Year by IBC Conferences, and under his leadership of Research and Development, his Executive Team (RADEX) received the Scrip Award for Management Team of the Year. He was the recipient of two Honorary Doctorates (West Virginia University and University of Catania, Italy) and two Lifetime Achievement Awards (Ohio State University and Scrip Awards). He has published in excess of 500 full-length papers, edited 15 books and was the Editor-in-Chief of four international pharmacology journals.